Biacore™ 1S+ SPR system

CYTIVA

Biacore™ 1 series systems is a one-needle platform with six flow cells that transforms protein interaction analysis using surface plasmon resonance (SPR) — making it simpler and faster to use without compromising quality. Now you can focus on generating the consistent and reproducible data needed in your research.

Our Biacore 1 series SPR systems come in three configurations: Biacore 1K, Biacore 1K+ and Biacore 1S+. The systems offer analytical flexibility that can grow with your group’s need for sample capacity, sensitivity, and throughput.

All systems are built for analysis in a GxP-regulated environment. The single software platform for Biacore 1 series systems speeds up time to results and reduces training needs. Application methods are easily transferred to other labs or to other Biacore 1 series systems and the higher throughput Biacore 8 series systems.

You can use Biacore 1 series systems across a wide range of applications, molecules, and both pure and complex samples — from small fragments to large viruses. The systems are scalable so your research will not be limited as your needs evolve.

Analysis temperature : 4°C to 40°C (at least 20°C below ambient temperature)
Analysis time per cycle : Typically 2 to 15 min
Application : Kinetic characterization (Biacore Single Cycle Kinetics (SCK)™ and Biacore Multi Cycle Kinetics (MCK)™), affinity characterization, concentration and potency analysis, epitope binning, selectivity studies, kinetic screening single concentration, LMW interaction analysis, fragment screening (Clean screen, Binding level screen, Affinity screen), buffer scouting, competition assay, multi-complex analysis
Association rate constant (ka) : Proteins: up to 3 × 109 M-1 s-1
Automation : 72 h unattended operation
Baseline noise : Typically < 0.01 RU (RMS)
Capacity : 2 × 96- or 384-well microplates, normal, and deep-well 2 × reagent racks with 21–43 positions compatible with 0.7–4.4 mL vials
Detection technology : Surface plasmon resonance (SPR) biosensor
Dissociation rate constant (kd) : 10-6 to 6 s-1
Flow cell volume : 60 nL
Flow rate : 1 to 100 μL/min
In-line reference subtraction : Automatic
Includes : Biacore™ 1S+ instrument, 2 licenses of Biacore™ Insight Software
Injection volume : 1 to 400 μL
Mains requirement : Processing unit: Autorange voltage 100 to 240 V~, frequency 50/60 Hz
Molecular weight detection : No lower limit for organic molecules
Number of flow cells : 6 in 1 channel
Power consumption : Processing unit: max. 350 VA
Refractive index : 1.33 to 1.39
Sample concentration min. : ≥ 1 picomolar (pM)
Sample type : Small-molecule drug candidates to high-molecular weight proteins (also DNA, RNA, polysaccharides, lipids, cells, and viruses) in various sample environments (e.g., in DMSO-containing buffers, plasma, and serum)
Sample volume min. : Injection volume plus 20 to 40 μL (application dependent)
Weight : 96 kg
Dimensions (W × H × D) : 755 × 725 × 666 mm
Short term noise : Typically < 0.3 RU/min
Baseline subtracted drift : < +/-0.003 RU/min

Biacore™ 1S+ SPR system

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